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In fact i just sent an email to my doc to let me off the methotrexate since the side effects are so crappy.

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It interacts with a number of other drugs, including warfarin and methotrexate.

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pharmacokinetic monitoring of methotrexate serum concentrations may help identify those patients at high risk for methotrexate toxicity and aid in proper adjustments of leucovorin dosing.

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